However, some candidate genes may not be involved in TSD per se. The basic pattern of gonad development is conserved in reptiles [ Raynaud and Pieau, ; Morrish and Sinclair, ]. Expression of putative sex-determining genes during the thermosensitive period of gonad development in the snapping turtle, Chelydra serpentina.
Expression differences are taken as evidence that the gene of interest is involved in TSD. Oestrogens and temperature-dependent sex determination in reptiles: all is in the gonads. Female rodents, sheep, and primates treated prenatally or postnatally with dihydrotestosterone develop a phenotype that mimics polycystic ovary syndrome [ Abbott et al.
Fundamental similarities in gonad development are evident at the genetic, molecular, cellular, developmental, and physiological levels in all vertebrates. Expression of sex steroid hormone-related genes in the embryo of the leopard gecko. Taken together, these observations indicate that genes transduce temperature into a biological signal for sex determination.
Alternative pre-mRNA splicing: the logic of combinatorial control.
We have confirmed that temperature influences expression of these genes using independent biological samples and quantitative PCR using the methods described in Rhen et al. Sign Up. Gonad Differentiation The basic pattern of gonad development is conserved in reptiles [ Raynaud and Pieau, ; Morrish and Sinclair, ].
For instance, polychlorinated biphenyls PCBs are pollutants whose molecules are structurally similar to some estrogens. Mammalian sex determination: A molecular drama. Ramsey and Crews,