It also potentiates insulin-stimulated glucose uptake and utilization. These observed anti-diabetic actions suggest additional benefits of the CS and T—2 ABCA1 peptide agonists for cardiovascular disease beyond their direct anti-atherosclerosis properties previously described.
The specific amino acid motifs of ATI responsible for its toxic effects were identified and substituted with other relevant amino acids using an iterative screening process. These screening efforts lead to the discovery of a second generation ABCA1 agonist family with identification of two lead peptides, CS and T—2, both of which were found to be non-toxic and did not cause an increase in triglyceride levels Bielicki et al.
We next assessed whether CS was effective in inhibiting in vitro glucose production in human Huh-7 and rat H4IIE hepatic cell lines. IDF Diabetes Atlas —, eighth ed.
Abrevaya, J. Notes 1. Acknowledgements This manuscript is taken from my graduate dissertation, and I am greatly indebted to my advisors, David Card and Ronald Lee, for their counsel and support. Results are available upon request. The article has three objectives: first, to introduce a novel, multilevel spatial model of regional.
Others have advocated a re-laxation of the One Child Policy to allow more parents to have a son without engaging in sex selection. Son preference, sex ratios, and marriage patterns. Evidence from birth data. The article has three objectives: first, to introduce a novel, multilevel spatial model of regional.
In contrast, peptides 4, 5, 6 and 9 had no discernible effect on plasma glucose levels. Impact of specific glucose-control strategies on microvascular and macrovascular outcomes in 58, adults with type 2 diabetes. Fredric B.